DGMP metabolic process

Across TCGA cell cohorts, RNA activity of the DGMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNPH1, PLPBP, and MMRN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DGMP metabolic process activity versus DNPH1 in CNS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DNPH1 →	+1.603	+1.726	<.001	<.001	3	5
STOMACH	PLPBP →	+1.218	+1.795	.001	<.001	3	5
STOMACH	MMRN2 →	-1.157	-1.518	.006	<.001	3	5
BREAST	SELENBP1 →	+2.882	+0.740	.006	.006	3	5
OESOPHAGUS	TADA1 →	+0.596	+1.405	.008	.001	3	4
SKIN	PLEKHJ1 →	+0.893	+1.306	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046054 vs DNPH1 — CNS

Explore this scatter interactively →