DAMP metabolic process

Across TCGA patient cohorts, RNA activity of the DAMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, FERMT3, and SASH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DAMP metabolic process activity versus ADA in GBM (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADA →	+0.519	+0.078	<.001	<.001	3	8
UCEC	FERMT3 →	+0.551	+0.088	<.001	.003	3	7
UCEC	SASH3 →	+0.355	+0.082	.001	.002	3	6
BRCA	PRKAR2A →	-0.207	-0.062	<.001	<.001	3	6
OV	NFIA →	-0.355	-0.055	.002	.004	3	6
GBM	P3H1 →	+0.478	+0.055	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046053 vs ADA — GBM

Explore this scatter interactively →