DAMP metabolic process

Across TCGA patient cohorts, RNA activity of the DAMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRBV19, CCL4, and ITGAX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DAMP metabolic process activity versus TRBV19 in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRBV19 →	+1.227	+0.162	<.001	.003	3	6
UCEC	CCL4 →	+1.584	+0.237	<.001	<.001	3	6
HNSC	ITGAX →	+0.838	+0.118	<.001	<.001	3	5
LSCC	DUSP2 →	+0.497	+0.081	.006	.005	3	5
LSCC	ARHGAP4 →	+0.422	+0.115	.009	.001	3	5
UCEC	IFI30 →	+0.670	+0.202	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046053 vs TRBV19 — UCEC

Explore this scatter interactively →