DAMP metabolic process

Across TCGA cell cohorts, RNA activity of the DAMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNP, APEX1, and LAMA5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DAMP metabolic process activity versus PNP in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PNP →	+0.765	+1.240	.001	<.001	3	6
LUNG_NSCLC_LUAD	APEX1 →	+0.371	+0.777	.007	.001	3	5
STOMACH	LAMA5 →	-1.884	-1.261	.006	.002	2	5
BREAST	FAM186B →	-0.310	-1.130	.002	<.001	3	4
LUNG_SCLC	PAQR4 →	+0.987	+1.140	<.001	.007	3	4
STOMACH	H2BC9 →	-1.328	-1.301	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046053 vs PNP — LUNG_SCLC

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