IMP metabolic process

Across TCGA patient cohorts, RNA activity of the IMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KCNAB2, SAMSN1, and WIPF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP metabolic process activity versus KCNAB2 in OV (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KCNAB2 →	+0.746	+0.276	<.001	.002	3	5
UCEC	SAMSN1 →	+0.568	+0.166	<.001	.001	3	4
BRCA	WIPF1 →	+0.361	+0.177	<.001	<.001	3	4
BRCA	DOK2 →	+0.535	+0.186	<.001	<.001	3	4
GBM	INPP5D →	+0.552	+0.120	.001	.001	3	4
GBM	MAPK14 →	+0.241	+0.103	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046040 vs KCNAB2 — OV

Explore this scatter interactively →