IMP metabolic process

Across TCGA cell cohorts, RNA activity of the IMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK13, DLG3, and TMEFF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAPK13 grouped by IMP metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAPK13 →	+3.046	+1.022	.001	.008	3	4
STOMACH	DLG3 →	+2.341	+1.120	.009	.006	3	4
BLOOD_Myeloma	TMEFF1 →	-2.007	-0.406	<.001	.001	2	5
STOMACH	KIRREL1 →	-3.423	-0.849	<.001	.009	2	5
STOMACH	CD2AP →	+0.887	+0.770	.001	.006	3	4
LUNG_NSCLC_LUSC	NUP62CL →	+1.620	+0.433	.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAPK13 by IMP metabolic process activity — STOMACH

Explore this box plot interactively →