IMP metabolic process

Across TCGA cell cohorts, RNA activity of the IMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYC, ANKRD13B, and THOP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, IMP metabolic process activity versus MYC in LUNG_SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MYC →	+4.646	+0.473	<.001	<.001	3	7
LUNG_SCLC	ANKRD13B →	+1.139	+0.348	.003	.006	3	7
BONE	THOP1 →	+0.840	+0.540	.007	.007	3	7
BLOOD_Lymphoma	PPAT →	+0.878	+0.257	<.001	<.001	2	7
LUNG_SCLC	EEF2 →	+0.929	+0.403	.001	.003	3	6
BONE	MLST8 →	+1.058	+0.578	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046040 vs MYC — LUNG_SCLC

Explore this scatter interactively →