GTP metabolic process

Across TCGA patient cohorts, RNA activity of the GTP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMPD1, LY9, and TBC1D27P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GTP metabolic process activity versus AMPD1 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AMPD1 →	+0.436	+0.175	.002	.002	3	5
LSCC	LY9 →	+0.532	+0.210	<.001	<.001	3	5
LSCC	TBC1D27P →	+0.465	+0.186	<.001	<.001	3	5
BRCA	IRF4 →	+0.806	+0.160	.001	<.001	3	5
UCEC	SIRPG →	+0.676	+0.110	.002	.002	3	5
LSCC	SH3TC1 →	+0.756	+0.188	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046039 vs AMPD1 — LSCC

Explore this scatter interactively →