GMP metabolic process

Across TCGA cell cohorts, RNA activity of the GMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFLNB, ARHGEF26, and EXO5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RFLNB grouped by GMP metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RFLNB →	-3.275	-0.735	<.001	<.001	3	4
STOMACH	ARHGEF26 →	-2.400	-0.582	.004	.004	3	3
LUNG_NSCLC_LUAD	EXO5 →	-0.763	-0.337	.002	.008	3	3
LUNG_NSCLC_LUAD	SMIM26 →	+0.678	+0.523	.001	.009	3	3
STOMACH	SNX24 →	-1.640	-0.488	.007	.002	3	3
STOMACH	PRSS16 →	+2.188	+0.719	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RFLNB by GMP metabolic process activity — STOMACH

Explore this box plot interactively →