GMP metabolic process

Across TCGA cell cohorts, RNA activity of the GMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, GATAD2A, and CHERP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, GMP metabolic process activity versus ANKRD13B in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANKRD13B →	+1.846	+0.466	.001	.001	3	6
LIVER	GATAD2A →	+1.422	+0.390	.002	<.001	3	5
BONE	CHERP →	+1.057	+0.521	<.001	.002	3	5
LARGE_INTESTINE	DPH5 →	+0.781	+0.356	.001	<.001	3	5
BLOOD_Lymphoma	POLR3D →	+0.729	+0.262	.007	<.001	2	6
LUNG_SCLC	ATP1A3 →	+2.258	+0.302	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046037 vs ANKRD13B — STOMACH

Explore this scatter interactively →