ATP metabolic process

Across TCGA patient cohorts, RNA activity of the ATP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRGAP3_S858, VIM_S430, and CASP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP metabolic process activity versus SRGAP3_S858 in GBM (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRGAP3_S858 →	+0.657	+0.031	<.001	.001	3	4
CCRCC	VIM_S430 →	-0.642	-0.030	<.001	.002	3	4
GBM	CASP4 →	-0.331	-0.027	.003	.001	3	4
GBM	CDS1_S9 →	+1.221	+0.050	<.001	<.001	3	4
GBM	GOT1 →	+0.769	+0.054	<.001	<.001	3	4
PDAC	PLS3_S339 →	-0.531	-0.030	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046034 vs SRGAP3_S858 — GBM

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