ATP metabolic process

Across TCGA patient cohorts, RNA activity of the ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB, NDC80, and PIMREG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATP metabolic process activity versus TUBB in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TUBB →	-0.403	-0.122	.005	.002	3	6
UCEC	NDC80 →	-0.912	-0.202	.001	.005	3	5
UCEC	PIMREG →	-0.648	-0.159	.003	<.001	3	5
LSCC	DAP3 →	-0.366	-0.125	.006	.009	3	5
UCEC	GNL2 →	-0.516	-0.241	.002	<.001	3	5
CCRCC	IKBIP →	-0.382	-0.155	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046034 vs TUBB — LSCC

Explore this scatter interactively →