AMP metabolic process

Across TCGA patient cohorts, RNA activity of the AMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12A_S445, VIM_S226, and ADSS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP metabolic process activity versus PPP1R12A_S445 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPP1R12A_S445 →	+0.925	+0.191	<.001	<.001	3	5
PDAC	VIM_S226 →	+0.995	+0.182	<.001	<.001	3	4
COAD	ADSS1 →	+1.106	+0.233	.007	.002	1	6
OV	ANKS6_S657 →	+0.650	+0.234	.002	.003	3	4
OV	KCNAB2 →	+1.125	+0.521	<.001	.002	3	4
PDAC	LGALS1_S30 →	+0.688	+0.210	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046033 vs PPP1R12A_S445 — OV

Explore this scatter interactively →