AMP metabolic process

Across TCGA cell cohorts, RNA activity of the AMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN4, MSRB3, and PROS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAVIN4 grouped by AMP metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CAVIN4 →	-0.326	-0.465	.007	.007	3	5
LUNG_SCLC	MSRB3 →	-2.731	-0.830	.001	.001	3	4
STOMACH	PROS1 →	-3.066	-0.517	<.001	<.001	2	5
OVARY	EVPL →	+2.389	+1.069	<.001	<.001	3	4
CNS	C11orf45 →	+0.787	+0.884	.003	<.001	3	4
LUNG_NSCLC_LUAD	SEC23B →	+0.998	+0.851	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAVIN4 by AMP metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →