AMP metabolic process

Across TCGA cell cohorts, RNA activity of the AMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN11, CSNK1G2, and MRPL16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP metabolic process activity versus PTPN11 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PTPN11 →	+0.837	+0.397	.004	<.001	3	7
STOMACH	CSNK1G2 →	+1.032	+0.345	<.001	.001	3	7
BREAST	MRPL16 →	+0.621	+0.213	.002	.003	3	6
SKIN	BBS7 →	+0.503	+0.368	<.001	<.001	3	6
STOMACH	RNF126 →	+0.922	+0.319	<.001	.003	3	6
LIVER	HNRNPA1 →	+0.674	+0.476	.008	.006	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046033 vs PTPN11 — PANCREAS

Explore this scatter interactively →