Regulation of transcription by glucose

Across TCGA patient cohorts, RNA activity of the Regulation of transcription by glucose pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPP1_S195, BMP1, and PKM_S249, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription by glucose activity versus SPP1_S195 in PDAC (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SPP1_S195 →	-0.692	-0.033	.003	.005	3	6
LUAD	BMP1 →	-0.422	-0.046	.004	.001	3	6
CCRCC	PKM_S249 →	-0.538	-0.033	.005	.009	3	5
HNSC	ATRX_S84 →	+0.229	+0.037	.002	.003	3	5
COAD	USP7 →	+0.184	+0.042	<.001	<.001	3	5
GBM	CHD4 →	+0.257	+0.030	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046015 vs SPP1_S195 — PDAC

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