Regulation of transcription by glucose

Across TCGA patient cohorts, RNA activity of the Regulation of transcription by glucose pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTM1, TMEM119, and DHRS7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription by glucose activity versus MTM1 in LUAD (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTM1 →	-0.297	-0.610	.002	.002	3	4
BRCA	TMEM119 →	-1.062	-0.675	.001	.006	3	4
LUAD	DHRS7 →	-0.484	-0.782	<.001	<.001	3	3
LUAD	TNFSF10 →	-0.560	-0.503	.001	.002	3	3
LUAD	PRRG1 →	-0.290	-0.503	.004	.002	3	3
LUAD	MSI2 →	+0.379	+0.599	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046015 vs MTM1 — LUAD

Explore this scatter interactively →