Regulation of transcription by glucose

Across TCGA cell cohorts, RNA activity of the Regulation of transcription by glucose pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHCBP1, KAT2B, and C1orf116, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription by glucose activity versus SHCBP1 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SHCBP1 →	+1.270	+0.153	<.001	<.001	3	9
SKIN	KAT2B →	+1.818	+0.105	<.001	<.001	3	9
URINARY_TRACT	C1orf116 →	-2.265	-0.080	.007	.005	3	8
OVARY	MCMBP →	+0.757	+0.076	<.001	<.001	3	8
BLOOD_Myeloma	MND1 →	+1.259	+0.088	<.001	<.001	3	8
PANCREAS	KIF11 →	+0.949	+0.098	.008	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046015 vs SHCBP1 — PANCREAS

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