Regulation of embryonic development

Across TCGA patient cohorts, RNA activity of the Regulation of embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS17, MMP16, and MIR3174, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of embryonic development activity versus RPS17 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS17 →	+0.576	+0.248	<.001	<.001	3	4
PDAC	MMP16 →	+0.404	+0.133	.007	.001	3	3
PDAC	MIR3174 →	-0.315	-0.139	.004	<.001	3	3
HNSC	TGFB1I1 →	+0.721	+0.292	.001	.005	3	3
HNSC	TGIF1P1 →	+0.626	+0.246	.004	.003	3	3
HNSC	ANP32BP3 →	+1.020	+0.258	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045995 vs RPS17 — BRCA

Explore this scatter interactively →