Regulation of embryonic development

Across TCGA patient cohorts, RNA activity of the Regulation of embryonic development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK4_S1717, ANLN_S642, and TAF6_S653, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of embryonic development activity versus DOCK4_S1717 in LSCC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK4_S1717 →	-1.057	-0.199	<.001	<.001	3	3
BRCA	ANLN_S642 →	+1.891	+0.216	<.001	<.001	3	3
HNSC	TAF6_S653 →	-0.384	-0.309	<.001	<.001	3	3
LSCC	SYNM →	-0.583	-0.204	.002	.003	3	2
OV	TJP1_S912 →	-1.026	-0.265	<.001	<.001	3	2
BRCA	BRPF1 →	+0.338	+0.249	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045995 vs DOCK4_S1717 — LSCC

Explore this scatter interactively →