Regulation of embryonic development

Across TCGA cell cohorts, RNA activity of the Regulation of embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC9B, DUSP15, and GPN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC9B grouped by Regulation of embryonic development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCDC9B →	+2.415	+0.113	.002	.002	3	4
SKIN	DUSP15 →	+1.443	+0.142	<.001	<.001	3	3
LARGE_INTESTINE	GPN3 →	-0.516	-0.099	.005	.004	3	3
LARGE_INTESTINE	AMD1 →	-0.713	-0.146	.002	<.001	3	3
SOFT_TISSUE	C5orf34 →	-1.015	-0.203	<.001	<.001	3	3
LARGE_INTESTINE	FITM2 →	+0.635	+0.117	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC9B by Regulation of embryonic development activity — STOMACH

Explore this box plot interactively →