Carbon catabolite regulation of transcription

Across TCGA patient cohorts, RNA activity of the Carbon catabolite regulation of transcription pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, FBLN5, and PBK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbon catabolite regulation of transcription activity versus SAMHD1 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMHD1 →	+0.509	+0.098	.001	<.001	3	6
CCRCC	FBLN5 →	+0.944	+0.050	.001	.001	3	6
LUAD	PBK →	-0.686	-0.069	<.001	<.001	3	6
HNSC	SVIL_S547 →	+0.551	+0.074	.002	.001	3	6
LSCC	NEXN_S226 →	+0.753	+0.093	.001	<.001	3	6
BRCA	CLIC2 →	+0.436	+0.042	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045990 vs SAMHD1 — HNSC

Explore this scatter interactively →