Carbon catabolite regulation of transcription

Across TCGA patient cohorts, RNA activity of the Carbon catabolite regulation of transcription pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPAT2P2, MTCO1P27, and NOP58, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbon catabolite regulation of transcription activity versus GPAT2P2 in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPAT2P2 →	+0.770	+0.803	<.001	<.001	3	3
BRCA	MTCO1P27 →	+0.233	+0.483	.005	.005	3	3
LSCC	NOP58 →	+0.436	+0.663	.002	.003	3	3
UCEC	MTCYBP3 →	-1.432	-0.841	.001	.001	3	3
UCEC	MRPS21 →	+0.577	+0.605	.002	.001	3	3
BRCA	RASSF2 →	+0.506	+0.633	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045990 vs GPAT2P2 — LSCC

Explore this scatter interactively →