Carbon catabolite regulation of transcription

Across TCGA cell cohorts, RNA activity of the Carbon catabolite regulation of transcription pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FPGS, PPARD, and C8orf33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FPGS grouped by Carbon catabolite regulation of transcription-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FPGS →	-0.813	-0.469	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PPARD →	-1.254	-0.343	<.001	<.001	3	4
CNS	C8orf33 →	+0.411	+0.456	.001	.002	3	3
KIDNEY	BCL9 →	+1.048	+0.331	.003	.002	3	3
LIVER	NEURL1B →	-1.721	-0.503	.001	<.001	3	3
LIVER	PITPNM3 →	-2.102	-0.478	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FPGS by Carbon catabolite regulation of transcription activity — LIVER

Explore this box plot interactively →