Positive regulation of striated muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of striated muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSN_S527, PPP1R18_S368, and SREK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of striated muscle contraction activity versus MSN_S527 in CCRCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MSN_S527 →	+0.722	+0.075	.001	.002	3	7
LSCC	PPP1R18_S368 →	+0.617	+0.080	<.001	.003	3	7
GBM	SREK1 →	-0.284	-0.088	<.001	<.001	3	6
UCEC	SYNPO_S854 →	+0.479	+0.102	.001	<.001	3	6
LUAD	TCEAL4 →	-0.350	-0.068	.003	.002	3	6
GBM	TNRC6B_S385 →	+0.375	+0.075	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045989 vs MSN_S527 — CCRCC

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