Positive regulation of striated muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01732, TREML4, and VSTM2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of striated muscle contraction activity versus LINC01732 in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LINC01732 →	-0.238	-0.236	.007	.006	3	4
HNSC	TREML4 →	-0.300	-0.070	.007	.003	3	4
GBM	VSTM2A →	+1.396	+0.077	.001	.009	3	3
GBM	PPA1 →	+0.433	+0.097	.004	.004	3	3
GBM	DGAT2L6 →	-0.259	-0.080	.006	<.001	3	3
UCEC	GPN1 →	-0.650	-0.179	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045989 vs LINC01732 — PDAC

Explore this scatter interactively →