Negative regulation of striated muscle contraction

Across TCGA patient cohorts, RNA activity of the Negative regulation of striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRAM1, IFFO1, and RASAL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle contraction activity versus PRAM1 in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRAM1 →	+0.603	+0.233	.001	<.001	3	6
BRCA	IFFO1 →	+0.676	+0.363	.001	<.001	3	5
LSCC	RASAL3 →	+0.720	+0.495	<.001	.006	3	5
LSCC	ARHGAP9 →	+0.704	+0.593	<.001	<.001	3	5
COAD	PREX1 →	+0.694	+0.205	<.001	.003	3	5
LSCC	WDFY4 →	+0.668	+0.565	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045988 vs PRAM1 — HNSC

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