Negative regulation of striated muscle contraction

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT7, LMBR1, and MFSD9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRT7 grouped by Negative regulation of striated muscle contraction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRT7 →	+2.528	+0.616	.007	.002	3	4
KIDNEY	LMBR1 →	+1.028	+1.556	.002	<.001	3	3
KIDNEY	MFSD9 →	+0.502	+1.334	.004	<.001	3	3
OVARY	ARHGEF1 →	+0.741	+0.891	.004	.002	3	3
BLOOD_Myeloma	ZNF211 →	+1.247	+1.977	.004	<.001	3	3
BLOOD_Leukemia	ITGA5 →	-1.353	-0.709	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRT7 by Negative regulation of striated muscle contraction activity — BREAST

Explore this box plot interactively →