Negative regulation of striated muscle contraction

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANTXR1, MAG, and FASTKD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle contraction activity versus ANTXR1 in BLOOD_Leukemia (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANTXR1 →	-1.897	-0.196	.008	.006	3	4
SKIN	MAG →	+6.446	+0.210	<.001	.001	3	3
LIVER	FASTKD2 →	-0.469	-0.351	<.001	.007	3	3
BLOOD_Leukemia	APEX1 →	+1.012	+0.255	<.001	.004	3	3
LUNG_NSCLC_LUSC	UFL1 →	-1.136	-0.496	.007	.001	3	3
BLOOD_Leukemia	OAZ3 →	-0.639	-0.216	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045988 vs ANTXR1 — BLOOD_Leukemia

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