Positive regulation of smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ID3, TEAD3, and ZNF23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ID3 grouped by Positive regulation of smooth muscle contraction-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ID3 →	+3.980	+1.624	.002	.005	3	5
SKIN	TEAD3 →	+1.220	+1.130	<.001	<.001	3	5
URINARY_TRACT	ZNF23 →	+0.819	+1.310	<.001	<.001	3	5
CNS	GLIS3 →	-1.388	-0.800	.007	.004	3	4
LIVER	PSMB6 →	+0.730	+1.255	<.001	<.001	3	4
SKIN	RAB6A →	+0.503	+0.882	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ID3 by Positive regulation of smooth muscle contraction activity — LIVER

Explore this box plot interactively →