Positive regulation of smooth muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of smooth muscle contraction pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, PCBP2, and SNX30, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of smooth muscle contraction activity versus ITGA2 in URINARY_TRACT (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ITGA2 →	+2.711	+0.360	<.001	<.001	3	7
STOMACH	PCBP2 →	-1.069	-0.393	.007	.001	3	5
BLOOD_Leukemia	SNX30 →	+0.994	+0.970	.003	.004	2	6
SOFT_TISSUE	SEPTIN6 →	-1.445	-0.314	.001	.002	3	4
SOFT_TISSUE	MICAL2 →	+3.810	+0.404	.009	.001	2	5
LUNG_NSCLC_LUAD	SLC7A6OS →	+0.553	+0.150	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045987 vs ITGA2 — URINARY_TRACT

Explore this scatter interactively →