Negative regulation of smooth muscle contraction

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of smooth muscle contraction pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and LUSC, show the opposite pattern, with lower activity in tumor tissue.

HNSC, UCEC, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	All	II,III,IV	+0.037	<.001	9	view →
UCEC	All	All	−0.093	<.001	8	view →
LUSC	Female	All	−0.092	<.001	8	view →
COAD	Female	All	−0.050	<.001	8	view →
THCA	Male	All	−0.051	<.001	7	view →
KIRC	Male	II,III,IV	−0.035	<.001	7	view →
KIRP	All	All	−0.034	<.001	7	view →
BRCA	All	III,IV	−0.108	<.001	6	view →
LUAD	All	III,IV	−0.055	.006	3	view →
LIHC	All	II,III,IV	−0.020	.017	3	view →
BLCA	Male	All	−0.053	.017	2	view →
KICH	All	All	−0.032	.003	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0045986–HNSC

Open the HNSC breakdown →