Positive regulation of nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WWTR1, MAP1B_S995, and SLC9A3R2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleotide metabolic process activity versus WWTR1 in GBM (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WWTR1 →	-0.281	-0.039	.005	.003	3	5
LSCC	MAP1B_S995 →	-0.972	-0.040	<.001	<.001	3	4
CCRCC	SLC9A3R2 →	+0.354	+0.033	<.001	.001	3	4
CCRCC	NRBF2 →	-0.305	-0.031	<.001	.001	3	4
BRCA	AP1G2 →	-0.312	-0.029	<.001	<.001	3	4
BRCA	MYO10 →	+0.363	+0.024	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045981 vs WWTR1 — GBM

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