Positive regulation of nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCH1, CTNNBL1, and DDX11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleotide metabolic process activity versus GCH1 in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GCH1 →	-0.307	-0.392	.004	.007	3	3
LUAD	CTNNBL1 →	-0.251	-0.698	.003	<.001	3	3
LUAD	DDX11 →	-0.559	-0.507	<.001	.004	3	3
UCEC	VAMP1 →	-0.547	-0.681	<.001	.001	3	3
LUAD	LRRC63 →	-0.291	-0.684	.001	.001	3	3
UCEC	CERS5 →	-0.402	-0.718	<.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045981 vs GCH1 — LUAD

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