Positive regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleotide metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTOR, RPTOR, and PTPN9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTOR grouped by Positive regulation of nucleotide metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MTOR →	-0.474	-0.239	<.001	<.001	3	9
STOMACH	RPTOR →	-0.367	-0.272	<.001	.002	3	8
CNS	PTPN9 →	-0.116	-0.211	.004	.003	3	5
UPPER_AERODIGESTIVE_TRACT	MUC13 →	+0.248	+0.426	.002	<.001	3	4
STOMACH	FLOT2 →	+0.158	+0.189	<.001	.009	3	4
STOMACH	SELP →	+0.148	+0.229	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTOR by Positive regulation of nucleotide metabolic process activity — STOMACH

Explore this box plot interactively →