Positive regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PQBP1, VCP, and SNCG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PQBP1 grouped by Positive regulation of nucleotide metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PQBP1 →	-0.680	-0.170	.009	<.001	3	4
OESOPHAGUS	VCP →	-0.629	-0.169	.001	.005	3	4
PANCREAS	SNCG →	-3.615	-0.190	<.001	.001	3	4
SKIN	UBAP2 →	-0.689	-0.271	<.001	<.001	3	4
KIDNEY	BTD →	-1.202	-0.340	.003	.002	3	4
KIDNEY	VASH1 →	-1.118	-0.262	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PQBP1 by Positive regulation of nucleotide metabolic process activity — LIVER

Explore this box plot interactively →