Positive regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL1, TMSB4X, and HDX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleotide metabolic process activity versus UCHL1 in BLOOD_Lymphoma (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UCHL1 →	+5.998	+0.329	<.001	<.001	3	5
LUNG_SCLC	TMSB4X →	+2.286	+0.258	<.001	.002	3	5
KIDNEY	HDX →	+0.917	+0.258	.001	<.001	3	5
OVARY	CRYBG2 →	-1.766	-0.284	.007	.003	3	5
SOFT_TISSUE	TLN2 →	-2.276	-0.303	.003	.002	3	4
BLOOD_Leukemia	ITGAL →	+2.940	+0.162	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045981 vs UCHL1 — BLOOD_Lymphoma

Explore this scatter interactively →