Negative regulation of nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of nucleotide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, SERPINA7, and C8G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nucleotide metabolic process activity versus TIMP2 in BRCA (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.461	+0.031	.005	.008	3	5
CCRCC	SERPINA7 →	+0.390	+0.070	.001	<.001	3	5
CCRCC	C8G →	+0.555	+0.095	<.001	<.001	3	5
CCRCC	CYGB →	+0.388	+0.066	.006	.003	3	5
PDAC	COL1A1 →	+0.542	+0.084	<.001	<.001	3	5
PDAC	COL4A1 →	+0.307	+0.053	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045980 vs TIMP2 — BRCA

Explore this scatter interactively →