Negative regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of nucleotide metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53BP1, TP53, and MDM4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TP53BP1 grouped by Negative regulation of nucleotide metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TP53BP1 →	-0.355	-1.763	<.001	<.001	3	11
SOFT_TISSUE	TP53 →	-0.820	-1.510	<.001	<.001	3	11
SOFT_TISSUE	MDM4 →	+0.564	+1.294	<.001	.004	3	9
SKIN	MDM2 →	+0.622	+0.939	<.001	<.001	3	8
SKIN	CDKN1A →	-0.572	-1.309	<.001	<.001	3	7
SOFT_TISSUE	RNF123 →	-0.322	-1.777	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TP53BP1 by Negative regulation of nucleotide metabolic process activity — OVARY

Explore this box plot interactively →