Negative regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNG1, ZMAT3, and SNX10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNG1 grouped by Negative regulation of nucleotide metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCNG1 →	-0.891	-1.145	.001	.004	3	6
KIDNEY	ZMAT3 →	-1.431	-1.403	.001	<.001	3	5
SKIN	SNX10 →	-2.400	-1.557	<.001	<.001	3	4
KIDNEY	CDKN1A →	-2.320	-1.761	.007	<.001	3	4
OVARY	RRM2B →	-0.868	-0.849	.004	.005	3	4
KIDNEY	MDM2 →	-1.614	-1.504	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNG1 by Negative regulation of nucleotide metabolic process activity — OVARY

Explore this box plot interactively →