Negative regulation of nucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIM1, LMNA, and DENND2D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nucleotide metabolic process activity versus CRIM1 in SKIN (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRIM1 →	-2.429	-0.229	.004	.004	3	4
BLOOD_Lymphoma	LMNA →	-2.541	-0.227	<.001	<.001	3	4
SKIN	DENND2D →	+1.550	+0.271	.003	.004	3	4
BLOOD_Lymphoma	CAPN2 →	-3.572	-0.230	<.001	<.001	3	4
SKIN	CKAP2L →	-0.899	-0.249	<.001	.003	3	4
SKIN	MSRB3 →	-1.120	-0.201	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045980 vs CRIM1 — SKIN

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