Positive regulation of calcium ion-dependent exocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA2, ASPA, and SYT7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion-dependent exocytosis activity versus ABCA2 in GBM (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ABCA2 →	+0.616	+1.057	<.001	<.001	3	4
GBM	ASPA →	+1.005	+1.093	<.001	<.001	3	4
GBM	SYT7 →	+1.392	+1.364	<.001	<.001	3	4
BRCA	PPP4R4 →	+1.013	+0.597	.009	.002	3	4
GBM	SCN2B →	+1.171	+1.383	<.001	<.001	3	4
GBM	TEF →	+0.685	+0.755	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045956 vs ABCA2 — GBM

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