Positive regulation of calcium ion-dependent exocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEFB1, SLC25A40, and RPL13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEFB1 grouped by Positive regulation of calcium ion-dependent exocytosis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFB1 →	+0.259	+0.937	.002	.002	3	4
BLOOD_Myeloma	SLC25A40 →	+1.229	+1.374	.007	.003	2	4
SOFT_TISSUE	RPL13 →	-0.437	-1.217	.007	.003	3	3
SOFT_TISSUE	H2BC17 →	+0.986	+1.195	.009	.001	3	3
LUNG_NSCLC_LUSC	ATG5 →	-0.696	-1.177	.004	.008	3	3
LIVER	SYF2 →	-0.613	-1.426	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEFB1 by Positive regulation of calcium ion-dependent exocytosis activity — SKIN

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