Positive regulation of calcium ion-dependent exocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSTL1, CYTH3, and ZP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion-dependent exocytosis activity versus FSTL1 in LIVER (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FSTL1 →	-4.821	-0.092	.007	.008	3	6
SKIN	CYTH3 →	-0.936	-0.699	<.001	<.001	3	6
BLOOD_Leukemia	ZP3 →	+1.128	+0.387	<.001	.001	3	6
LUNG_SCLC	BIRC2 →	-0.759	-0.105	<.001	.004	3	6
LUNG_NSCLC_LUAD	QKI →	-1.598	-0.122	<.001	<.001	3	5
LUNG_SCLC	WTIP →	-1.538	-0.181	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045956 vs FSTL1 — LIVER

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