Positive regulation of calcium ion-dependent exocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF3B, PHF19, and H2BC11, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion-dependent exocytosis activity versus KIF3B in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KIF3B →	+0.778	+1.014	<.001	<.001	3	2
LUNG_SCLC	PHF19 →	+0.748	+1.360	.003	<.001	3	2
LUNG_SCLC	H2BC11 →	+1.890	+1.145	.001	<.001	3	2
LUNG_SCLC	TNFSF13 →	+1.176	+1.004	.003	<.001	3	2
LUNG_SCLC	TRMT11 →	-0.689	-1.086	.003	.003	3	2
BONE	CLPP →	-0.794	-1.719	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045956 vs KIF3B — LUNG_SCLC

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