Positive regulation of translational initiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GIMAP8, FERMT3, and ARRB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translational initiation activity versus GIMAP8 in CCRCC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GIMAP8 →	+0.347	+0.040	<.001	.002	3	6
COAD	FERMT3 →	+0.347	+0.023	.001	.008	3	6
OV	ARRB1 →	+0.278	+0.034	.005	.001	3	5
COAD	SCRIB_T1342 →	-0.247	-0.020	.004	<.001	3	5
COAD	TBC1D1 →	+0.324	+0.024	.001	.001	3	5
GBM	DHX32 →	-0.260	-0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045948 vs GIMAP8 — CCRCC

Explore this scatter interactively →