Positive regulation of translational initiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD1, HACL1, and ASIC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translational initiation activity versus KCTD1 in BLOOD_Leukemia (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCTD1 →	+1.718	+0.133	.004	.005	3	4
UPPER_AERODIGESTIVE_TRACT	HACL1 →	-0.888	-0.261	<.001	.008	3	4
PANCREAS	ASIC1 →	-0.948	-0.168	<.001	.002	3	4
CNS	USP45 →	-0.426	-0.188	.006	.008	3	4
LARGE_INTESTINE	DENND10 →	-0.617	-0.204	.006	.002	3	3
LARGE_INTESTINE	MRPL15 →	-0.711	-0.213	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045948 vs KCTD1 — BLOOD_Leukemia

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