Negative regulation of translational initiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADNP, FNBP4, and PRPF4B, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of translational initiation activity versus ADNP in SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	ADNP →	+1.331	+0.106	<.001	<.001	3	34
UVM	FNBP4 →	+1.406	+0.061	<.001	<.001	3	34
UVM	PRPF4B →	+1.600	+0.059	<.001	<.001	3	34
UVM	INO80D →	+1.137	+0.065	<.001	<.001	3	34
DLBC	GON4L →	+1.267	+0.089	<.001	.001	3	34
CHOL	RCOR3 →	+1.448	+0.062	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045947 vs ADNP — SCLC

Explore this scatter interactively →