Negative regulation of translational initiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARID4B, RALY, and UTP15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of translational initiation activity versus ARID4B in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARID4B →	+0.227	+0.046	.002	.001	3	6
HNSC	RALY →	+0.273	+0.087	<.001	.001	3	6
LUAD	UTP15 →	+0.265	+0.039	.002	.001	3	6
CCRCC	UTP4 →	+0.127	+0.030	<.001	<.001	3	6
OV	STIM1_S257 →	-0.628	-0.045	.006	.001	3	6
LSCC	CWC22 →	+0.255	+0.051	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045947 vs ARID4B — LSCC

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