Negative regulation of translational initiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PML, G3BP1, and IFI44, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of translational initiation activity versus PML in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PML →	+1.655	+0.248	.001	.006	3	6
LUNG_SCLC	G3BP1 →	+0.542	+0.122	.005	.003	2	7
LARGE_INTESTINE	IFI44 →	+1.634	+0.200	.002	<.001	3	5
LIVER	NIBAN1 →	+3.362	+0.218	.002	.007	3	4
KIDNEY	ATXN1 →	+1.057	+0.197	.004	.008	3	4
LARGE_INTESTINE	DDX58 →	+1.163	+0.147	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045947 vs PML — LIVER

Explore this scatter interactively →